Arginine as a Solubilizing Agent: Application to Poorly Soluble Drugs
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چکیده
منابع مشابه
Nanonization strategies for poorly water-soluble drugs.
Poor water solubility for many drugs and drug candidates remains a major obstacle to their development and clinical application. Conventional formulations to improve solubility suffer from low bioavailability and poor pharmacokinetics, with some carriers rendering systemic toxicities (e.g. Cremophor(®) EL). In this review, several major nanonization techniques that seek to overcome these limita...
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Submit Manuscript | http://medcraveonline.com J Anal Pharm Res 2015, 1(1): 00001 in terms of dissolution but the non-traditional formulation approaches can lead to a significant increase in dissolution and solubility particularly required for drugs applied in medium to higher dosages [3]. Such dosages’ requirements go along with the necessity to evaluate other formulation technologies for enhan...
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The solubilizing ability of two aromatic hydrotropes, N,N-diethylnicotinamide (DENA) and N,N-dimethylbenzamide (DMBA), was investigated using a set of 13 poorly soluble, structurally diverse drugs. The number of aromatic rings in the solute molecule has a very strong effect on the solubility enhancement produced by either hydrotrope. However, although solubility enhancements in the order of 100...
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Solubility of drug plays critical role in achieving the optimum therapeutic levels of the drug in blood and thus bioavailability. There are many drugs of various therapeutic categories fall in BCS class II and IV as they lack solubility. For all these drugs dissolution is the big hurdle for the absorption process. Present review’s focus is mainly on novel techniques of improving the solubility ...
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Among all newly discovered chemical entities about 40% drugs are lipophillic and fail to reach market due to their poor water solubility. Drug with poor water solubility cause slow dissolution rates, generally show erratic and incomplete absorption leading to low bioavailability when administered orally. Aqueous solubility of any therapeutically active substance is a key property, as it governs...
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ژورنال
عنوان ژورنال: Seibutsu Butsuri
سال: 2014
ISSN: 0582-4052,1347-4219
DOI: 10.2142/biophys.54.026